I would say Cyberpunk 2077, but that's apparently not coming until at least next year. Supposedly, there will be more details on it at this year's E3 though, so that's something to look forward to.
Yeah if this was a 2019 list Cyberpunk would have to be on there.
But for this year? There's some neat stuff on the radar... but if I had to pick one...
All systems nominal.
MechWarrior 5: Mercenaries! Which I am hoping makes the 2018 window and doesn't slip.