Biostar TA990FXE Problems

I recently purchased a Biostar TA990FXE AM3+ for my machine that I'm upgrading. I got everything hooked up, new drivers installed and everything seemed to be going fine. I loaded up game of League of Legends and once the actual game loaded up, my sound became garbled and mouse/keyboard commands stopped being recognized. The game itself continued to play, I just couldn't do anything but watch what happened.

The keyboard and mouse still lit up but wouldn't respond to any commands despite disconnecting and reconnecting the USB connectors. I was forced to reset the machine which booted up fine and seemed to be working normally again. I tried to reproduce the issue by loading up another game of League. This time I was able to play for about 40 minutes before the exact same problem happened again.

At this point I contacted Biostar and began looking up if this issue had occurred for others but wasn't having much luck on either side. I updated my BIOS verified that the latest drivers for everything were installed. At this point I thought maybe it was a problem with League and tried a few other games. The issue occurred the same way for any game I played and for videos too, it even happened once when I was just sitting at desktop with nothing running.

Biostar requested that I ship them the motherboard, which I did but they were unable to reproduce the error after running it through 3D Mark for 72 hours. What else could this be?

Maybe some sort of incompatibility between the game and your hardware? Just guessing. It doesn't sound as if your hardware is faulty in any way.

I'm mainly concerned with if this problem could be caused by anything other than the Motherboard. If it's the board I can try to get it replaced as it's still within warranty..