Can I delete duplicate files, even if they are in separate directories

I just ran a utility that finds duplicate files. The names and sizes are exactly the same, but each are in different directories. Can I delete all dups that are in these different directories?? What if a program/code calls for a file in a absolute path and it doesn't find it. Is code that smart these days that it will look in another location?

for example, qfe.exe is found in multiple files.

c:\DELL\drivers\R147115\gfe.exe
c:\DELL\drivers\R153908\HDAQFE\win2k_xp\us\gfe.exe
c:\Program Files\SigmaTel\C-Major Audio\HDAQFE\win2k_xp\us\gfe.exe

I know the answer may seem obvious, but I thought I'd better ask that to create havoc on my computer....

thanks for your advice!

Simple. - You are dealing with system files - Leave the duplicates Alone !

Same to you, and your's !

As you say, The most complete duplicate finder and deleter I have found is "Duplicate Files Deleter".

You can download it from here: http://duplicatefilesdeleter.com/

I have found that, not only is it one of the fastest duplicate finders/deleters, but also is by far the most accurate one because of the way it's search engine uses MD5 info.

Yes, the duplicate file finder i tried for the purpose did it. I tried Mac duplicate finder program and it cleared all duplicate & temporary files from my system within matter of moments. My experience with the program was really nice and i would recommend this to all. Find More information on mac duplicate finder program here and it is also to be noted that the program is safe & easy to use and wont delete system files, thereby helping system work properly after the duplicate file entries have been cleared.