Oh, you bet it can!!
PC maker CyberPower posted on its Facebook page showing an EVGA setup with four GeForce GTX 480s in a very impressive 4-way SLI setup. According to Techpowerup, EVGA tested the cards on a X58 Classified 4-way SLI motherboard with a special SLI bridge that makes it all possible.
Sadly, no benchmark results yet, but with such a graphical monster on EVGA's hands, we don't imagine details to be secret for very long.