External Hard Drive files missing

I want to ask can external hard drive delete what it stored in it by it's own? I had a file called autorun.inf on almost all my external hard disks I do not know if it is from the disk itself to run without problem or it means the hard disk in infected with something like a virus , can this file affect my external hard disk and can lead to loss my files?
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More about external hard drive files missing
  1. Antivirus programs often misinterpret them as malware and delete them.
    Reply to CountMike
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