Will Using NTFS Compression Slow Down Programs?

Will using NTFS Compression on files that programs must frequently access slow down the program? For example if i compressed the folder in which League of Legends stores all of its data will it slow down the game or effect performance in any way, as i've heard that accessing compressed files when using NTFS Compression can slow down the speed of which those files are accessed by the user but does this also apply to programs that access those said files?

Computer Specs:
Ryzen 5 1600
EVGA | Geforce GTX 1080 Ti
Seagate Barracuda Hard Drive 4TB
16Gb HyperX 2667mhz RAM
Reply to 1738hughmungus
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