I did some research on your motherboard. It looks like you have an Intel i5 or i7 4XXX in there. The Hyper 212 Evo fits the LGA1150 socket so you'll have no problem with the pins lining up. As far as the RAM goes, you should be fine there. The layout is similar to any other motherboard. The fan can be adjusted to slide up a bit just in case or you could orient the cooler in a different direction. The NZXT S340 will allow for the height of the cooler as well. You'll be fine.