What is the real life performance difference between NVME and SATA SSD's?

Hi, i am building a build and want to know what real life performance difference is between NVME PCIE SSD's and SATA SSD's. I know that NVME will have a 3-4x faster read/write speed, but what does that transfer to in game loading times and copying/moving files? Also, side question, does the 5-20 MB difference in read/write speeds on SATA really matter?
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  1. depend how much data you are transferring
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