Shadows and Anti-aliasing need to be turned down for sure.
0x Anti Aliasing
Shadows : low-medium
Shader Quality: low-medium
Reflection Quality: low
Post fx: low/off
Ambient occlusion: low/off
Tessellation: off - keep this one off.
Vsync: Off - keep this one off.
You can mess around with those settings yourself, I found those ones in specific to have the largest affect on fps.
Also it be worth turning distance scaling down and population density.
I put all of that down to minimum and it seems to have helped a little bit, It also got rid of some small lag spikes I had